3 ECTS credits
78 u studietijd

Aanbieding 1 met studiegidsnummer 4022180DNR voor alle studenten in het 2e semester met een inleidend master niveau.

Semester
2e semester
Inschrijving onder examencontract
Niet mogelijk
Beoordelingsvoet
Beoordeling (0 tot 20)
2e zittijd mogelijk
Ja
Inschrijvingsvereisten
To subscribe for this course, you must simultaneously subscribe for Laboratory animal science I and II. Or have passed Laboratory animal science I and II.
Onderwijstaal
Engels
Faculteit
Faculteit Geneeskunde en Farmacie
Verantwoordelijke vakgroep
Basis (bio-) medische wetenschappen
Onderwijsteam
Karine Breckpot
Karine Hellemans
Nico Buls
Karlijn Debusschere (titularis)
Onderdelen en contacturen
0 contacturen Exam
31 contacturen Lecture
Inhoud

Laboratory Animal Science is a multidisciplinary field that covers different aspects encountered when working with laboratory animals. It focuses on the welfare and care of animals used in research, taking into account both animal- as well as experiment-related factors. Knowledge within the field of laboratory animal science will contribute  to the reliability and reproducibility of animal experiments and learn the students how to handle laboratory animals in a responsible and respectful manner.

According to the Belgian legislation (RD of May 29th 2013) there are 4 levels of education that permit you to work with laboratory animals:

1) Elementory care of laboratory animals – minimum of 4 hrs of education in laboratory animal science

2) Specialised care of laboratory animals – minimum of 25 hrs of education in laboratory animal science

3) Active participants in animal experimentation – minimum of 40 hrs of education in laboratory animal science

4) Responsible for directing animal experiments (proefleider) - minimum of 80 hrs of education in laboratory animal science

Laboratory animal science is subdivided into 3 courses, that correspond to the 4 categories within the Belgian legislation:

  • Laboratory Animal Science 1: total of 25 hrs of education, corresponding to category 2 in the Belgian legislation - Specialised care of laboratory animals
  • Laboratory Animal Science 2: total of 40 hrs of education, corresponding to category 3 in the Belgian legislation - Active participants in animal experimentation
  • Laboratory Animal Science 3: total of 80 hrs of education, corresponding to category 4 in the Belgian legislation - Responsible for directing animal experiments

This series of course is recognised by the overseeing government, Leefmilieu Brussels.

Within Laboratory Animal Science 3, students will get acquainted with the following subjects:

  • Practical application of European and Belgian legislation concerning all aspects of animal experimentation
  • Rodent health management and monitoring and the influence on research
  • Research project-related topics
    • Ethical committee
    • Design of animal experiments
    • Statistical analysis
  • Animal facility design and managment
  • Immunology and applications within the field of (bio-)medical research
  • Basic principles of xenotransplantation
  • Medical imaging of laboratory animals, including radioprotection
  • Good Laboratory Practices
  • Behavioral assessment techniques in laboratory Rodents
  • Pharmacology, pharmacokinetics and pharmacodynamics
  • Genetic standardization and transgenesis
  • Animal models in research

Practical:

  • Guided tour imaging facility (if possible)
Studiemateriaal
Praktisch cursusmateriaal (Vereist) : Proefdierkunde 3, Nota's opgesteld door de titularis, aangevuld met wetenschappelijke artikels of brochures worden bij de aanvang van iedere les uitgedeeld.
Handboek (Aanbevolen) : Clinical Laboratory Animal Medicine, An Introduction, Colby - Nowland - Kennedy, 5de, Wiley-Blackwel, 9781119489566, 2019
Bijkomende info

This course is recognised by the overseeing government, Leefmilieu Brussels. Passing the exam (min. 10/20) gives you permission to work with laboratory animals as defined by art. 32§5 of the RD May 29th 2013, category 4 – Responsible for directing animal experiments (proefleider). 

To subscribe for this course, you must simultaneously subscribe for Laboratory animal science I and II. Or have passed Laboratory animal science I and II or any equivalent courses.  

Leerresultaten

Algemene competenties

In art. 32§5 of the RD May 29th 2013 concerning the protection of animals used in experiments the Department of Animal Welfare stipulated the legal requirements that must be met to be allowed to work with laboratory animals. After following the course Laboratory Animal Science 3, students must:

  • Be able to find definitions and legislation related to animal experimentation and use the European and Belgian legislation to solve cases
  • Have a thorough knowledge of immunology and applications in biomedical research
  • Understand the principles behind animal facility design and animal facility management and find flaws in facility designs
  • Understand the basic principles of xenotransplantation and possible problems that come with it
  • Have knowledge of different (pre-clinical) medical imaging devices and techniques and apply this knowledge in experimental designs and when evaluating experiments
  • Have a good understanding of radioprotection and the practical implications
  • Have a thorough knowledge of the working mechanisms and tasks of an ethical committee and be able to apply this knowledge in a practical setting
  • Be able to apply for an animal experiment
  • Be able to study the literature, prepare and critically analyze research protocols
  • Be able to understand and work out an experimental design with statistical analysis
  • Understand the principle and work flows of Good Laboratory Practices (GLP)
  • Have a theoretical knowledge of pharmacology, pharmacokinetics and pharmacodynamics
  • Know and understand techniques for behavioral assessment of laboratory animals
  • Have a basic understanding on how to choose the correct animal model
  • Have good knowledge and be able to apply knowledge in genetic standardization and transgenesis

Beoordelingsinformatie

De beoordeling bestaat uit volgende opdrachtcategorieën:
Examen Schriftelijk bepaalt 90% van het eindcijfer

ZELF Groepswerk bepaalt 10% van het eindcijfer

Binnen de categorie Examen Schriftelijk dient men volgende opdrachten af te werken:

  • Written exam met een wegingsfactor 1 en aldus 90% van het totale eindcijfer.

    Toelichting: Written exam: open questions (cases) and multiple choice

Binnen de categorie ZELF Groepswerk dient men volgende opdrachten af te werken:

  • EC application met een wegingsfactor 1 en aldus 10% van het totale eindcijfer.

    Toelichting: Group assignment with peer-feedback: write an ethical application based on published research

Aanvullende info mbt evaluatie

Examination will be at the end of the course (June exams) by means of a written exam (90% of the total score). Retake of the written exam is possible in the second examination period.

Students will submit a group assignment, with peer-feedback, where they have to write an ethical application based on the methodology of an experiment in a paper. This will be evaluated and included into the endpoint (10%). The scoring of the peer-feedback will result in an individual adjustment factor to individualize the group-score by multiplying the individual adjustment factor with the group score. The teacher always has the right to change these adjustment factors if there is reason to believe the adjustment factor is not to be trusted.

If a student has to retake the exam, the partial result of the group assignment will be transferred to the second examination period when the student has received 10/20 or higher for this part. Otherwise, an alternative assignment will be given for the group assignment.

If Laboratory animal science (I), II and III are taken up simultaneously, they can only receive a credit for Laboratory animal science III if they pass laboratory animal science I and II or have equivalent credits for Laboratory Animal Sciences I and II.

Toegestane onvoldoende
Kijk in het aanvullend OER van je faculteit na of een toegestane onvoldoende mogelijk is voor dit opleidingsonderdeel.

Academische context

Deze aanbieding maakt deel uit van de volgende studieplannen:
Master in de biomedische wetenschappen: biomedisch onderzoek
Master in de biomedische wetenschappen: management en bedrijfsleven
Master in de biomedische wetenschappen: klinische biomedische wetenschappen
Master of Biology: Molecular and Cellular Life sciences (enkel aangeboden in het Engels)
Master of Biomedical Research: Standaard traject (enkel aangeboden in het Engels)